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Located right in the heart of Downtown St. Louis, 21c Museum Hotel St. Louis has been transformed into boutique hotel and art gallery from a 10-story YMCA building. Close to where the hotel has been reconstructed are family friendly entertainment venues such as Citypark Stadium and Citygarden Sculpture Park. Down a few blocks are restaurants such as Medina Grill, which offers mouthwatering Mediterranean classics, and Chris @ The Docket, for those who favor breakfast food any time of day. These spots are all within walking distance of 21c Musuem Hotel St. Louis and show a little of what the historic city of St. Louis has to offer.  

Nearest Airport

St. Louis Lambert International Airport 14 mi, 21 minutes.    

Hotel Address

1528 Locust Street, St. Louis

Missouri, United States 63103 

Historic Hotels of America Recommended Points of Interest

  • Gateway Arch

    Gateway Arch

    A curved, 630-ft.-tall monument celebrating US western expansion, with views from the top and also a museum. 

  • Gateway Arch Museum

    Gateway Arch Museum

    Explore the history of the American West at the Gateway Arch Museum.

  • Saint Louis Art Museum

    Saint Louis Art Museum

    Explore some of the finest art in the country at the Saint Louis Art Museum.

  • Saint Louis Zoo

    Saint Louis Zoo

    Free 90-acre zoo featuring animals such as penguins, bears & elephants, plus a train ride.

  • St. Louis Aquarium At Union Station

    St. Louis Aquarium at Union Station

     Explore the St. Louis Aquarium at Union Station, one of the most unique indoor attractions in St. Louis. 

  • Tower Grove Park

    Tower Grove Park

    Spend time outside in St. Louis at Tower Grove Park.