21c Museum Hotel Louisville by MGallery

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Awards & Accolades

2022 Historic Hotels of America Awards of Excellence Nominee Finalist

Distinctive & Notable



Located within Louisville’s exciting West Main Street Historic District is the 21c Museum Hotel Louisville: the flagship establishment of 21c Museum Hotels. It has many pieces of contemporary artwork, including a fantastic remake of Michelangelo’s David situated just beyond its front door. The current building is composed of five historical warehouses that once catered to the tobacco and bourbon merchants that frequented the city’s vibrant riverside port. One of the structures even served as the lucrative Falls City Tobacco Bank for several decades during the mid-1800s. Since 2006, these marvelous historical buildings have together formed the 21c Museum Hotel Louisville. The hotel features 91 guestrooms and contemporary art museum.

21c Museum Hotel Louisville has been named to these Historic Hotels of America Top 25 Lists

The 2022 Top 25 Historic Hotels of America Most Magnificent Art Collections

Location Map

Explore Frazier History Museum, the Muhammad Ali Center, and the Louisville Slugger Museum & Factory nearby. Churchill Downs is a short drive away.


Discover the Romanesque façade of the 21c Museum Hotel Louisville by MGallery.


Explore the iconic Louisville Slugger Museum & Factory.


Experience a gallery tour of the 21c Museum Hotel Louisville by MGallery.


Taste one of the more than 120 Kentucky bourbons at Proof on Main, the signature restaurant of the 21c Museum Hotel Louisville by MGallery.

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